TY  - JOUR
AU  - CHANG Lin
AU  - XU Jian-xin
AU  - ZHAO Jing
AU  - PANG Yong-zheng
AU  - TANG Chao-shu
AU  - QI Yong-fen
PY  - 2016
TI  - Taurine antagonized oxidative stress injury induced by homocysteine in rat vascular smooth muscle cells
JF  - Acta Pharmacologica Sinica; Vol 25, No 3 (March 2004): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - AIM:  To observe protective effects of taurine on reactive oxygen species generation induced by homocysteine in rat vascular smooth muscle cells (VSMC).  METHODS:  Rat VSMC was incubated with various concentrations of homocysteine and taurine. The lactate dehydrogenase (LDH) activity which released into culture medium was elevated as an indicator for VSMC injury. The reactive oxygen species (ROS)--hydrogen peroxide (H2O2) and superoxide anion (O2(-*)) were measured with luminol or lucigenin chemiluminescence method, and the mitochondria Mn-superoxide dismutase (Mn-SOD) and catalase (CAT) were also measured in treated VSMC.  RESULTS:  LDH leakage from cultured VSMC treated with homocysteine, was increased (P
UR  - http://www.chinaphar.com/article/view/7892