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Identification of genes responsive to apoptosis in HL-60 cells

   
@article{APS7889,
	author = {Wei JIN and Le-feng QU and Ping MIN and Shan CHEN and Hong LI and He LU and Yong-tai HOU},
	title = {Identification of genes responsive to apoptosis in HL-60 cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To identify genes responsive to apoptosis in HL-60 cells treated by homoharringtonine.
METHODS:
cDNA microarray technology was used to detect gene expression and the result of microarrays for genes (TIEG and VDUP1) was confirmed by Northern analysis.
RESULTS:
Seventy-five individual mRNAs whose mass changed significantly were identified. Among these genes (25 were up-regulated and 50 were down-regulated), most are known related to oncogenes and tumor suppressor. Some genes were involved in apoptosis signaling pathways.
CONCLUSION:
TGF beta and TNF apoptosis signaling pathways were initiated during apoptosis in HL-60 cells. TIEG and VDUP1 play important roles in mediating apoptosis.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7889}
}