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Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine

   
@article{APS7777,
	author = {Wen Dun and Rong-rui Zhao and Jian-guo Li and Bo-wei Wu},
	title = {Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the effects of propylbutyldopamine (PBDA) on the inward rectifier potassium current (Ik1).
METHODS:
The quasi-steady state current-voltage relationship from the isolated guinea pig ventricular cells were measured using whole-cell patch-clamp techniques with a slow ramp depolarization (8 mV.s-1).
RESULTS:
PBDA 5, 50, and 100 mumol.L-1 concentration-dependently reduced the inward rectifier potassium current. PBDA blocked Ik1 in guinea pig ventricular cells. The effect of PBDA was not blocked by the selective dopamine D2-receptor blocker, domperidone.
CONCLUSION:
PBDA inhibited Ik1 directly, independent of the dopamine D2-receptor.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7777}
}