%0 Journal Article
%T Effects of konjac extract on insulin sensitivity in high fat diet rats.
%A MAO Cai-Ping
%A XIE Mei-Lin
%A GU Zhen-Lun
%J Acta Pharmacologica Sinica
%D 2016
%B 2016
%9 
%! Effects of konjac extract on insulin sensitivity in high fat diet rats.
%K 
%X AIM: To evaluate the effects of konjac extract (KE) on insulin sensitivity in  insulin resistance (IR) rats induced by high fat diet (HFD).  METHODS: Wistar rats were fed on HFD for 4 weeks, then treated with KE 1.5, 3.0  g/kg/d and metformin (Met) 0.1 g/kg/d for 4 weeks, respectively. The effects of  KE on intake of food and drink, body weight, and excretion were investigated.  Serum insulin was measured by double-radioimmunoassay. Blood glucose, total  cholesterol (TC), triglycerides (TG), and high-density lipoprotein-cholesterol  (HDL-C) were measured by enzyme methods, respectively. Low-density  lipoprotein-cholesterol (LDL-C) was calculated. Tissue glycogen was determined by  modified anthracene ketone method and tissue TG by glycerin phosphor sour  oxidation enzyme method. Insulin sensitivity was measured by modified  glucose-insulin tolerance test (K value).  RESULTS: HFD caused IR after 4 weeks (K value: 5.2+/-0.9 vs 8.3+/-0.7, P
%U http://www.chinaphar.com/article/view/7763
%V 23
%N 9
%P 855-859
%@ 1745-7254