@article{APS7747,
author = {Yu-Hong YOU and Zhi-Bin LIN},
title = {Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen species.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {9},
year = {2016},
keywords = {},
abstract = {AIM: To study the protective effects of Ganoderma lucidum polysaccharides peptide
(GLPP) on the mice peritoneal macrophages injured by reactive oxygen species
(ROS), derived from tert-butylhydroperoxide (tBOOH) in vitro and in vivo.
METHODS: Mice peritoneal macrophages were injured by ROS, derived from tBOOH. The
survival rate of macrophages was measured by MTT assay, and the morphological
changes of macrophages were observed under light and electron microscopes.
RESULTS: GLPP (50, 100, 200 mg/kg, ip for 5 d) could inhibit the foam cell
formation and necrosis of macrophages. The survival rate of macrophages was
increased. GLPP (3.125, 12.5, 50, 200 mg/L) given to the cultured macrophages
brought the same protective effects. Under the electron microscope it was found
that GLPP (100 mg/kg, ip, for 5 d) could protect the organelle such as
mitochondria against injury by tBOOH.
CONCLUSION: GLPP had significant scavenging ROS and antioxidant effects.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7747}
}