@article{APS7734,
author = {Mei-Zi GUO and Xiao-Sheng LI and Hai-Rong XU and Zhe-Chuan MEI and Wei SHEN and Xiu-Feng YE},
title = {Rhein inhibits liver fibrosis induced by carbon tetrachloride in rats.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {8},
year = {2016},
keywords = {},
abstract = {AIM: To investigate the effect of rhein on liver fibrosis induced by the exposure
of carbon tetrachloride (CCl4)/ethanol in rats.
METHODS: Male Wistar rats were divided into four study groups (n=10 each group):
healthy controls, CCl4/ethanol-injured rats left untreated, and
CCl4/ethanol-injured rats treated with rhein of low-dose (25 mg/kg) and high-dose
(100 mg/kg). Rhein was given once a day since rat received CCl4/ethanol injury.
After administration of rhein for 6 weeks rats were killed. The following
parameters were determined: the activity of alanine aminotransferase (ALT),
hyalauronic acid (HA) and procollagen type III (PC-III) concentrations in serum,
liver malondialdehyde (MDA) level, the degree of liver fibrosis, and the
expression of alpha-smooth muscle actin (alpha-SMA) and transforming growth
factor-beta1 (TGF-beta1) in liver tissue.
RESULTS: The treatment of rhein markedly reduced the ALT activity, HA and PC-III
concentrations, and liver MDA level in CCl4/ethanol-injured rats (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7734}
}