%0 Journal Article %T Effect of intermittent injection of recombinant human parathyroid hormone on bone histomorphometry of ovariectomized rats. %A ZHANG Ke-Qin %A CHEN Jia-Wei %A LI Qing-Nan %A LI Guang-Fu %A TIAN Xiao-Yun %A HUANG Lian-Fang %A BAO Li-Hua %A WANG Mei-Lian %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Effect of intermittent injection of recombinant human parathyroid hormone on bone histomorphometry of ovariectomized rats. %K %X AIM: To observe the effect of intermittent parathyroid hormone (PTH) administration on bone histomorphology of relatively old ovariectomized rats. METHODS: The 6-month-old female SD rats were randomly divided into 5 groups: (1) sham-operated for baseline (ShamB, n=5), (2)ovariectomized for baseline (OVXB, n=6), (3) Sham-operated for end point (ShamE, n=6), (4) ovariectomized for end point (OVXE, n=6), (5) ovariectomized for PTH treatment (OVXEP, n=6). ShamB and OVXB rats were sacrificed 3 months after operation, ShamE, OVXE and OVXEP rats were sacrificed 4.5 months after operation. During 3-4.5 months after operation, OVXEP rats received daily subcutaneous injection of rhPTH1-84, while ShamE and OVXE received vehicle injection. The proximal tibiae of all rats were processed without decalcification for quantitative bone histomorphometry. RESULTS: The percent trabecular area (TbAr) of OVXEP was significantly greater than that of OVXE (P 0.05), but was smaller than that of ShamE (P 0.05). CONCLUSION: Short-term intermittent injection of rhPTH1-84 can prevent further bone loss in 9-month-old rats 3 months after ovariectomy, the mechanisms of this therapy are that PTH could increase TbTh while not alter TbN, and promote bone-forming activity while not influence bone-resorptive activity. %U http://www.chinaphar.com/article/view/7713 %V 23 %N 7 %P 659-662 %@ 1745-7254