@article{APS7692,
author = {Ning ZHONG and Qi-Zhi FANG and Yi ZHANG and Jing-Sheng XIA and Jian-Qing QIAN and Zhao-Nian ZHOU},
title = {Inhibitory effects of DDPH on two components of delayed rectifier potassium current in guinea pig ventricular cells.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {7},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of
1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxy-phenyl-ethylamino) propane
hydro-chloride (DDPH) on the rapidly activating component (I(Kr)), and the slowly
activating component (I(Ks)) of the delayed rectifier potassium current (I(K)) in
guinea pig ventricular myocytes.
METHODS: Whole-cell patch clamp recording techniques.
RESULTS: DDPH (0.1-100 micromol/L) blocked the I(Kr) in a concentration-dependent
manner. The IC50 (micromol/L) was 6.1 (95 % confidence limits: 2.8-13.5). IC50
(micromol/L) of DDPH blocking I(Ks) was 12.5 (95 % confidence limits: 4.8-32.2).
DDPH (10 micromol/L) did not affect activation time constants and the
voltage-dependent activation of both I(Kr) and I(Ks), the half-activation voltage
(V1/2, mV) and slope factor (k, mV) were I(Kr): -23.5+/-2.4 and 8.1+/-2.2 [in
presence of DDPH, P >0.05, compared with control, V1/2 (-21.7+/-0.8) and k
(5.9+/-0.8)]; I(Ks): 27.1+/-0.7 and 16.6+/-0.8 [in presence of DDPH, P >0.05,
compared with control, V1/2 (27.0+/-0.8) and k (14.9+/-0.9)]. DDPH slightly
increased the deactivation time-constant of I(Kr) ( r) and I(Ks) ( s) at low
concentration (},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7692}
}