TY - JOUR AU - Jin Bo AU - Dong Yu AU - Wang Hui-min AU - Huang Jin-su AU - Han Bao-hui PY - 2016 TI - Correlation between serum CEA levels and EGFR mutations in Chinese nonsmokers with lung adenocarcinoma JF - Acta Pharmacologica Sinica; Vol 35, No 3 (March 2014): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Bo JIN#, Yu DONG#, Hui-min WANG, Jin-su HUANG, Bao-hui HAN* Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China Aim: To evaluate the relationship between epidermal growth factor receptor (EGFR) mutations and serum carcinoembryonic antigen (CEA) levels in Chinese nonsmokers with pulmonary adenocarcinoma. Methods: We sequenced exons 18–21 of the EGFR gene in 98 cases. The patients were divided into two groups based on their pre-treatment serum CEA levels (below or above 5 ng/mL) for analyzing the correlations with EGFR mutations. Results: Sixty-seven cases harbored EGFR mutations. The rates of EGFR mutations and exon 19 mutations in the high-CEA group (78.2% and 49.1%, respectively) were significantly higher than those in the low-CEA group (55.8% and 20.9%, respectively). Serum CEA levels were found to be the only independent predictor of EGFR mutation (OR 2.837; 95% CI: 1.178–6.829) and exon 19 mutation (OR 3.618; 95% CI: 1.319–9.918). Furthermore, a higher serum CEA level was associated with a higher EGFR mutation rate and a higher exon 19 mutation rate: patients with serum CEA levels 5 ng/mL) than patients without EGFR mutations (64.2% vs 38.7%). Conclusion: Elevated serum CEA levels predict the presence of EGFR gene mutations in Chinese nonsmokers with pulmonary adenocarcinoma. Keywords: lung cancer; adenocarcinoma; biomarker; carcinoembryonic antigen; EGFR; mutation; exon 19 deletion; nonsmoker This work was supported by Key projects of Biomedicine Department, Science and Technology Commission of Shanghai Municipality (Project No 11411951200) and Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China (Project No Y211-12). # These authors contributed equally to this work. * To whom correspondence should be addressed. E-mail baohui.han@gmail.com Received 2013-06-04 Accepted 2013-10-08 UR - http://www.chinaphar.com/article/view/7671