@article{APS7671,
author = {Bo Jin and Yu Dong and Hui-min Wang and Jin-su Huang and Bao-hui Han},
title = {Correlation between serum CEA levels and EGFR mutations in Chinese nonsmokers with lung adenocarcinoma},
journal = {Acta Pharmacologica Sinica},
volume = {35},
number = {3},
year = {2016},
keywords = {},
abstract = {Bo JIN#, Yu DONG#, Hui-min WANG, Jin-su HUANG, Bao-hui HAN*
Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China
Aim: To evaluate the relationship between epidermal growth factor receptor (EGFR) mutations and serum carcinoembryonic antigen (CEA) levels in Chinese nonsmokers with pulmonary adenocarcinoma.
Methods: We sequenced exons 18–21 of the EGFR gene in 98 cases. The patients were divided into two groups based on their pre-treatment serum CEA levels (below or above 5 ng/mL) for analyzing the correlations with EGFR mutations.
Results: Sixty-seven cases harbored EGFR mutations. The rates of EGFR mutations and exon 19 mutations in the high-CEA group (78.2% and 49.1%, respectively) were significantly higher than those in the low-CEA group (55.8% and 20.9%, respectively). Serum CEA levels were found to be the only independent predictor of EGFR mutation (OR 2.837; 95% CI: 1.178–6.829) and exon 19 mutation (OR 3.618; 95% CI: 1.319–9.918). Furthermore, a higher serum CEA level was associated with a higher EGFR mutation rate and a higher exon 19 mutation rate: patients with serum CEA levels },
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7671}
}