@article{APS7597,
author = {Derek G Smyth and Jesus del Rio-garcia and Herwig Wallnofer and Harald Gogl and Wolfgang Simma and Ariana Huber and Robert Embacher and Hamish Fraser and Gunther Kreil},
title = {Protirelin (thyrotropin-releasing hormone) in thyroid gland: possible involvement in regulation of thyroid status},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM:
To establish the presence of the hypothalamic hormone protirelin (thyrotropin-releasing hormone, TRH) in human thyroid and to investigate whether the concentration of this peptide in the thyroid gland is sensitive to thyroid status.
METHODS:
A procedure has been developed for the determination of TRH in the thyroid gland, distinct from TRH-like peptides which also react with TRH-antibody.
RESULTS:
Human thyroid was shown to contain both authentic TRH and TRH-like peptides, a similar pattern was seen in a range of animal thyroids. The concentrations of TRH in non-active goiter thyroids were substantial (41.6-248 pmol.g-1); in contrast the thyroids from hyperthyroid patients contained very little TRH (0.01-2.52 pmol.g-1).
CONCLUSION:
The physiologic role of TRH in the thyroid is not known but the large difference between the concentrations of this hormone in non-active and hyperactive thyroids suggests that thyroidal TRH may be involved in the regulation of thyroid status.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7597}
}