TY - JOUR AU - Yang Qin AU - Lu Jing-Tao AU - Zhou Ai-Wu AU - Wang Bing AU - He Guo-Wei AU - Chen Min-Zhu PY - 2016 TI - Antinociceptive effect of astragalosides and its mechanism of action JF - Acta Pharmacologica Sinica; Vol 22, No 9 (September 2001): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aim: To study the effect and mechanism of astragalosides (AST) related to the antinociceptive activity. Methods: The standardized formalin test was performed to induce the direct stimulation of nociceptors followed by inflammatory process in the Kunming strain mice. The involvement of opioid and nitric oxide was studied by subcutaneous injection of morphine with/without naloxone 30 min before formalin test, or peritoneal injection of L-arginine with/without L-NAME 20 min before formalin. Results: AST 20, 40, and 80 mg/kg significantly lowered pain score of the second phase of formalin response as compared with control group (P Conclusion: AST has an antinociceptive effect on formalin test in mice that is not mediated by the endogenous opioid system but related to its inhibitory effect on the production of NO. UR - http://www.chinaphar.com/article/view/7595