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Antinociceptive effect of astragalosides and its mechanism of action

	author = {Qin Yang and Jing-Tao Lu and Ai-Wu Zhou and Bing Wang and Guo-Wei He and Min-Zhu Chen},
	title = {Antinociceptive effect of astragalosides and its mechanism of action},
	journal = {Acta Pharmacologica Sinica},
	volume = {22},
	number = {9},
	year = {2016},
	keywords = {},
	abstract = {Aim: To study the effect and mechanism of astragalosides (AST) related to the antinociceptive activity.
Methods: The standardized formalin test was performed to induce the direct stimulation of nociceptors followed by inflammatory process in the Kunming strain mice. The involvement of opioid and nitric oxide was studied by subcutaneous injection of morphine with/without naloxone 30 min before formalin test, or peritoneal injection of L-arginine with/without L-NAME 20 min before formalin.
Results: AST 20, 40, and 80 mg/kg significantly lowered pain score of the second phase of formalin response as compared with control group (P},
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