@article{APS7514,
author = {Zhong Chen and Ji-Qiang Chen and Chiaki Kamei},
title = {Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {7},
year = {2016},
keywords = {},
abstract = {Aim: To evaluate effects of certain H1-antagonists on spatial memory with 8-arm radial maze performance of rats.
Methods: Eight-arm radial maze performance was used to measure spatial memory in rats.
Results: Chronic treatments of classical H1-antagonists, diphenhydramine (5 mg/kg) and pyrilamine (20 mg/kg) impaired acquisition memory process regarding both parameters of radial maze performance. In addition, the memory retrieval process was also impaired significantly by a single administration of diphenhydramine (5, 10 mg/kg) and pyrilamine (50 mg/kg). However, the newly developed H1-antagonist, epinastine caused no appreciable effect on both acquisition and retrieval memory even at a high dose of 50 mg/kg. The memory deficit induced by diphenhydramine (10 mg/kg) or pyrilamine (50 mg/kg) was reversed by tacrine (1 mg/kg).
Conclusion: Histamine H(1)-receptors plays a certain role in spatial cognition, and its action may be due to both histaminergic and cholinergic neurons.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7514}
}