@article{APS7445,
author = {Feng Tao and Ling-mei Zhang and Feng-yan Sun},
title = {Hypoxia-ischemia altered expression of glutamate transporter EAAT1 in neonatal rat brain},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM:
To observe altered expression of glutamate transporter EAAT1 after hypoxia-ischemia (H-I) in newborn rat brain.
METHODS:
Expression levels of EAAT1 were detected with immunohistochemistry method.
RESULTS:
EAAT1 was a little expressed in cerebral cortex at sham-operated group [(36 +/- 10) cells/slice]. Its expression in cerebral cortex increased at 24 h and 48 h following H-I [(314 +/- 162) cells/slice and (431 +/- 149) cells/slice, respectively], and recovered to control level at 72 h following H-I [(52 +/- 8) cells/slice]. The expression of EAAT1 in the ipsilateral cortex to common carotid artery (CCA) ligation was higher than that in the contralateral cortex.
CONCLUSION:
After H-I, the expression of EAAT1 had a temporal change in cerebral cortex of newborn rat, and was mainly located in the ipsilateral cortex to CCA ligation.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7445}
}