%0 Journal Article %T Contractile responses of diabetic rat aorta to phenylephrine at different stages of diabetic duration %A Zhu Bang-Hao %A Guan Yong-Yuan %A Min Jun %A He Hua %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Contractile responses of diabetic rat aorta to phenylephrine at different stages of diabetic duration %K %X Aim: To investigate the time-dependent changes in contractile responses of aorta to phenylephrine (Phe) in diabetic rats and age-matched control, and its possible mechanism. Methods: At stages of 2-, 6-, and 12-week diabetic duration, aortic rings were studied for contractile responses to agonists in vitro. Results: At the stage of 2-week diabetic duration, contractile responses to lower concentrations of phenylephrine were increased (P Conclusion: The results suggested that contractile responses to phenylephrine in diabetic rat aorta changed with the development of diabetes, and the changes of functional Ca2+ store sizes and Ca2+ entry mainly through voltage-dependent Ca2+ channels were responsible for the alterations of contractile responses to phenylephrine in diabetes. %U http://www.chinaphar.com/article/view/7440 %V 22 %N 5 %P 445-449 %@ 1745-7254