%0 Journal Article %T Thrombolysis effect with FIIa from Agkistrodon acutus venom in different thrombosis model %A Chen Jia-Shu %A Liang Xiu-Xia %A Qiu Peng-Xin %A Yan Guang-Mei %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Thrombolysis effect with FIIa from Agkistrodon acutus venom in different thrombosis model %K %X Aim: A fibrinolytic enzyme from Agkistrodon acutus venom, called FIIa, was tested for thrombolytic activity in animals. Methods: Carotid thrombosis model in rats and rabbits and middle cerebral artery (MCA) thrombosis model in rats were used. Results: Intravenous administration of FIIa, at a dosage of 0.625 mg/kg, resulted in thrombolysis of carotid thrombi. However, in middle cerebral artery thrombosis, the effective thrombolysis dose was 1.25 mg/kg. When the dosage of FIIa increased, the thrombolytic effect was stronger. Histological examination of kidney, liver, heart, and lung tissue showed no hemorrhage. Conclusion: It shows that FIIa from Agkistrodon acutus venom is able to solubilize thrombus in vivo without hemorrhage at an effective dose for thrombolysis. %U http://www.chinaphar.com/article/view/7432 %V 22 %N 5 %P 420-422 %@ 1745-7254