@article{APS7432,
author = {Jia-Shu Chen and Xiu-Xia Liang and Peng-Xin Qiu and Guang-Mei Yan},
title = {Thrombolysis effect with FIIa from Agkistrodon acutus venom in different thrombosis model},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {5},
year = {2016},
keywords = {},
abstract = {Aim: A fibrinolytic enzyme from Agkistrodon acutus venom, called FIIa, was tested for thrombolytic activity in animals.
Methods: Carotid thrombosis model in rats and rabbits and middle cerebral artery (MCA) thrombosis model in rats were used.
Results: Intravenous administration of FIIa, at a dosage of 0.625 mg/kg, resulted in thrombolysis of carotid thrombi. However, in middle cerebral artery thrombosis, the effective thrombolysis dose was 1.25 mg/kg. When the dosage of FIIa increased, the thrombolytic effect was stronger. Histological examination of kidney, liver, heart, and lung tissue showed no hemorrhage.
Conclusion: It shows that FIIa from Agkistrodon acutus venom is able to solubilize thrombus in vivo without hemorrhage at an effective dose for thrombolysis.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7432}
}