TY - JOUR AU - Shan Hong-Li AU - Zhang Xiao-Dan AU - Gu Rui-Min AU - Luo Da-Li AU - Yang Bao-Feng PY - 2016 TI - Effects of erysimin G on renal tubular function and 70-pS K+ channel activity of thick ascending limb JF - Acta Pharmacologica Sinica; Vol 22, No 5 (May 2001): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aim: To study the effect of erysimin G (CH35H52O13) on the thick ascending limb (TAL) 70-pS K+ channel of rat kidney and its effect on diuresis. Methods: The patch-clamp cell-attached recording technique was used to record the single potassium channel current, and the urine volume (UV) was measured by urethral intubation to determine the diuretic effect. Results: Erysimin G can increase the urine volume and decrease the 70-pS potassium channel activity of TAL. Conclusion: Erysimin G has a diuretic effect and its inhibition on the activity of apical 70-pS potassium channel may be the mechanism of its diuretic effect. UR - http://www.chinaphar.com/article/view/7428