%0 Journal Article %T Kanglemycin C vs ciclosporin on immunosuppression in mice %A Li Jiang-ming %A Lin Zhi-bin %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Kanglemycin C vs ciclosporin on immunosuppression in mice %K %X AIM: To study inhibitory effects of kanglemycin C (Kan) on the mouse immune system, and compare with the effects of ciclosporin (Cic). METHODS: Delayed hypersensitivity (DH) and cyclophosphamide-potentiated DH induced by dinitrofluorobenzene (DNFB); heart allograft and skin allograft; hemolysin; the phagocytosis of the peritoneal macrophage. RESULTS: Kan (12.5, 25, 50 mg.kg-1.d-1, ig, 8 d) markedly inhibited DH and cyclophosphamide-potentiated DH induced by DNFB (P 0.05). CONCLUSION: Kan had marked suppressive effects on cell-mediated and humoral-mediated immune responses, but no effect on phagocytosis of macrophage. %U http://www.chinaphar.com/article/view/7425 %V 20 %N 1 %P 65-68 %@ 1745-7254