@article{APS7348,
author = {Xin-Bo Yang and Zheng-Ming Huang and Wen-Bin Cao and Ming Zheng and Hong-Yan Chen and Jing-Zhen Zhang},
title = {Antidiabetic effect of Oenanthe javanica flavone},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {3},
year = {2016},
keywords = {},
abstract = {\"AIM:
To study the antidiabetic effect of Oenanthe javanica flavone (OjF).
METHODS:
Mice were injected i.v. with alloxan 90 mg.kg-1 to induce diabetes. Blood glucose, serum lipid, and pancreatic amylase were determined with Automatic Biochemistry Analysor. Serum insulin was determined by radioimmunoassay. The pancreas and islets were examined under microscope.
RESULTS:
OjF 200 mg.kg-1 reduced the blood glucose in normal mice from 0.5 to 6 h after a single administration ig. OjF 200 and 400 mg.kg-1 ig daily for 10 d decreased the blood glucose in alloxan-induced hyperglycemic mice (P < 0.05, P < 0.01). OjF promoted the release of insulin both in normal and in diabetic mice. OjF decreased serum triglyceride and raised the lowered pancreatic amylases in diabetic mice (P < 0.01, P < 0.01). The islet-injured changes of OjF-treated group were similar to those of control in histology examination, but to a lesser degree.
CONCLUSION:
OjF possessed the hypoglycemic and hypotriglyceride actions, mainly concerned with promoting release of insulin from B-cells in islets of langerhans.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7348}
}