@article{APS7182,
author = {Yan-Rong SHI and Ding-Fang BU and Yong-Fen QI and Lin GAO and Hong-Feng JIANG and Yong-Zheng PANG and Chao-Shu TANG and Jun-Bao DU},
title = {Dysfunction of myocardial taurine transport and effect of taurine supplement in rats with isoproterenol-induced myocardial injury.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM: To study the alterations of myocardial taurine transport function, taurine
transporter (TAUT), and cysteine sulfinate decarboxylase (CSD) mRNA as well as
effect of exogenous taurine in rats with isoproterenol (ISO)-induced
cardiomegaly.
METHODS: [3H]-Taurine uptake and release on myocardium were determined. Binding
sites of [3H]-taurine for myocardial sarcolemma were measured. TAUT and CSD mRNA
levels were assayed using competitive quantitative reverse transcriptase
polymerase chain reaction (RT-PCR).
RESULTS: ISO group as compared with control group, myocardial taurine uptake
markedly reduced, taurine release obviously increased; Bmax value of [3H]-taurine
binding on cardiac sarcolemma reduced by 42% (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7182}
}