TY - JOUR AU - NIE Han-Xiang AU - YANG Jiong AU - HU Su-Ping AU - WU Xiao-Jun PY - 2016 TI - Effects of theophylline on CD4+ T lymphocyte, interleukin-5, and interferon gamma in induced sputum of asthmatic subjects. JF - Acta Pharmacologica Sinica; Vol 23, No 3 (March 2002): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - AIM: To investigate the mechanism of anti-inflammatory action of theophylline on asthma. METHODS: Nineteen asthmatic subjects were administered 200 mg sustained-release theophylline twice daily for 4 weeks. The number of CD4+ T lymphocytes, eosinophils, and the levels of interleukin (IL)-5 and interferon gamma (IFN-gamma) in sputum pre- and post-administration were measured by direct immunofluorescene technique, Wright's stain and enzyme-linked immunosorbent assay, respectively. The symptom scores and lung function were also evaluated. RESULTS: Theophylline treatment significantly improved symptom scores and FEV1.0, FEV1.0 % (P 0.05). The mean (range) serum theophylline concentration in final steady state was 7.9 (3.9 - 12.9) mg/L. CONCLUSION: The anti-inflammatory action of theophylline in asthma may result from reduction of IL-5 production in the airways. UR - http://www.chinaphar.com/article/view/7165