@article{APS7110,
author = {Hong-Li Peng and Dao-Feng Chen and Hong-Xiang Lan and Xue-Mei Zhang and Zheng Gu and Ming-Hua Jiang},
title = {Anti-lipid peroxidation of gomisin J on liver mitochondria and cultured myocardial cells},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM: To study the influences of gomisin J on lipid peroxidation and calcium paradox.
METHODS: Using two in vitro models of rat liver mitochondria membrane lipid peroxidation (LPO) and cultured myocardial cells.
RESULTS: Gomisin J inhibited Fe2+/ascorbic acid and ADP/NADPH-induced LPO with IC50 (95% confidence limits) 5.5 (4.5-6.7) and 4.7 (2.8-7.8) mumol.L-1, respectively, when cultured myocardial cells preincubated with Ca(2+)-free medium for 2 min were incubated with normal medium containing Ca2+, a marked increase of malondialdehyde (MDA) formation occurred and gomisin J 10 mumol.L-1 protected myocardial cells through decreasing MDA formation.
CONCLUSION: Gomisin J inhibits LPO in rat liver mitochondria and protects cultured myocardial cells from being injured by calcium paradox},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7110}
}