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Ciliary neurotrophic factor antagonizes gentamicin-induced alterations of electric potentials in auditory pathway in guinea pigs

   
@article{APS7098,
	author = {Cheng He and Song-Jian Kang and Ying Dou and Xian-Jun Shi and Cheng-Hai Wang and Shi-Zhou Ao and Chang-Lin Lu},
	title = {Ciliary neurotrophic factor antagonizes gentamicin-induced alterations of electric potentials in auditory pathway in guinea pigs},
	journal = {Acta Pharmacologica Sinica},
	volume = {17},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effects of ciliary neurotrophic factor (CNTF) on the expressions of gentamicin ototoxicity in guinea pigs.
METHODS: The auditory function of pigmented guinea pigs was examined using auditory brainstem response (ABR), cochlea microphonic potential (CM), and action potential of auditory nerve (AP).
RESULTS: In animals injected gentamicin (80 mg.kg-1.d-1, i.m.), ABR threshold began to elevate on d 20, and prolongations of ABR wave I, IV and the I-IV interpeak latencies were observed. The animals treated with gentamicin for 30 d displayed lower amplitudes of CM and AP (N1) than the controls. CNTF (0.44 mg.kg-1.d-1, s.c.) inhibited the gentamicin-induced elevation of ABR thresholds, the prolongation of ABR wave I, IV and the I-IV interpeak latencies, and the decreases in amplitudes of CM and AP (N1).
CONCLUSION: CNTF attenuated the gentamicin-elicited auditory impairment in guinea pigs.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7098}
}