@article{APS7080,
author = {Er-qing WEI and Xiao-hua XIN and Yao-chen WANG and Li-ping CHEN and Li-fen ZHANG and Ru-lian BIAN},
title = {Effects of ONO-1078, a leukotriene antagonist, on cardiovascular responses induced by vagal stimulation, capsaicin, and substance P in guinea pigs},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM:
To determine the role of ONO-1078, 4-oxo-8 -[p-(4-phenylbutyloxy) benzoylamino]- 2-(tetrazol-5-yl) -4H-1-benzopyran hemihydrate, in cardiovascular responses induced by vagal stimulation, capsaicin, and substance P.
METHODS:
Evans blue extravasation in the atrium and ventricle, and mean arterial pressure (MAP) were observed.
RESULTS:
Electric stimulation of vagus (ESV, 10 Hz, 5 ms, 2 or 10 V, for 90 s) increased Evans blue extravasation in the hearts of atropine (1 mg.kg-1, i.v.)-pretreated guinea pigs. Capsaicin (0.05 mg.kg-1, i.v.) and substance P (1 microgram.kg-1, i.v.) enhanced the dye extravasation and elicited a drop in MAP. ONO-1078 (0.03 and 0.1 mg.kg-1, i.v.) inhibited ESV-induced response, especially at stimulation of 2 V. ONO-1078 (0.03 mg.kg-1) attenuated capsaicin-induced cardiac microvascular leakage and hypotensive response, but failed to inhibit substance P-induced responses.
CONCLUSION:
ONO-1078 can modulate the cardiovascular responses in neurogenic inflammation, possibly mediated by inhibiting sensory neuropeptide release.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7080}
}