TY  - JOUR
AU  - Hong-xin WANG Hong-xin WANG
AU  - Wei-xin WANG Wei-xin WANG
PY  - 2016
TI  - Effects of nicorandil on spontaneous beating and action potentials of cultured myocardial cells of neonatal rats
JF  - Acta Pharmacologica Sinica; Vol 16, No 5 (September 1995): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - AIM:  To study the anti-arrhythmic mechanism of nicorandil (Nic).  METHODS:  The myocardial cells of neonatal rats were cultured and effects of Nic on spontaneous beating and action potential of cultured myocardial cells were observed.  RESULTS:  Nic 32 mumol L-1 and 160 mumol L-1 decreased the spontaneous beating rates of cultured myocardial cells of neonatal rats. Nic 64 mumol L-1 prevented the beating rats induced by CaCl2 1 mmol L-1 and isoproterenol 2 mumol L-1. Nic 32 and 160 mumol L-1 reduced the amplitude, maximal rate of rise, and shortened APD50 and APD90 repolarization. Nic prolonged the spontaneous sinus cycle length.  CONCLUSION:  The antiarrhythmic mechanism of Nic is related to its direct effects on the myocardial cells.
UR  - http://www.chinaphar.com/article/view/7078