%0 Journal Article
%T Effects of nicorandil on spontaneous beating and action potentials of cultured myocardial cells of neonatal rats
%A Hong-xin WANG Hong-xin WANG
%A Wei-xin WANG Wei-xin WANG
%J Acta Pharmacologica Sinica
%D 2016
%B 2016
%9 
%! Effects of nicorandil on spontaneous beating and action potentials of cultured myocardial cells of neonatal rats
%K 
%X AIM:  To study the anti-arrhythmic mechanism of nicorandil (Nic).  METHODS:  The myocardial cells of neonatal rats were cultured and effects of Nic on spontaneous beating and action potential of cultured myocardial cells were observed.  RESULTS:  Nic 32 mumol L-1 and 160 mumol L-1 decreased the spontaneous beating rates of cultured myocardial cells of neonatal rats. Nic 64 mumol L-1 prevented the beating rats induced by CaCl2 1 mmol L-1 and isoproterenol 2 mumol L-1. Nic 32 and 160 mumol L-1 reduced the amplitude, maximal rate of rise, and shortened APD50 and APD90 repolarization. Nic prolonged the spontaneous sinus cycle length.  CONCLUSION:  The antiarrhythmic mechanism of Nic is related to its direct effects on the myocardial cells.
%U http://www.chinaphar.com/article/view/7078
%V 16
%N 5
%P 477-480
%@ 1745-7254