@article{APS7076,
author = {S K DHAR and Sushma MATTU},
title = {Anti-implantation activity of 2 derivatives of o-hydroxy naphthaquinones in rats},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM:
To search for female contraceptive agents.
METHODS:
2-Hydroxy-3-methyl-1, 4-naphthoquinone monosemicarbazone (HMNQS) and 2-hydroxy-1, 4-naphthoquinone monothiosemicarbazone (HNQTS) were screened for anti-implantation activity in rats.
RESULTS:
Both compounds showed a dose-dependent activity, and HNQTS was more potent. An 100% anti-implantation activity was observed with HNQTS 150 mg kg-1 ig. Its LD50 was found to be > 2 g kg-1 ig in mice.
CONCLUSION:
HNQTS was more potent than HMNQS for anti-implantation activity in rats.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7076}
}