@article{APS7071,
author = {Geng-sheng YU and Ming-zhe CHEN and Qi-de HAN},
title = {Alterations of subtypes of cardiac adrenoceptors in old rat},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM:
To determine alterations of subtypes of myocardial adrenoceptors in senescence.
METHODS:
Heart membrane preparations were made from 3- and 25-month old Wistar rats. Alpha 1- and beta-adrenoceptors were measured by radioligand, 125I-BE2254 and 125I-pindolol, binding assays, respectively.
RESULTS:
In the old rat heart, alpha 1- and beta-adrenoceptor densities were declined from the young rats of 119 +/- 4 and 45.9 +/- 1.9 pmol L-1 to 70 +/- 6 and 36.4 +/- 1.6 pmol L-1 (P < 0.01), with a greater change in alpha 1-AR and in beta-AR. The ratio of alpha 1A/alpha 1B subtypes was decreased from the young rats of 39/61 to the old rats of 26/74 (P < 0.05).
CONCLUSION:
The cardiac adrenoceptors are decreased with different extents in the different subtypes in old rats.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7071}
}