@article{APS6983,
author = {Huai-Zhen Ruan and Xi-Cheng Li and Hai-Di Li and Bang-Yun Zhao},
title = {Somatostatin and electroacupuncture inhibited c-fos expression in spinal cord of arthritic rats},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM: To observer the effect of intrathecal injection of somatostatin (Som)
associated with electroacupuncture (EA) at \"\"Jiaji\"\" points on c-fos protein
expression of spinal cord in pain rats.
METHODS: Rats with adjuvant arthritis were used as pain model and the c-fos-like
immunoreactivity (FLI) was detected by immunohistochemistry.
RESULTS: The c-fos protein expression induced by arthritis were found in all of
the I-X laminae of ipsilateral spinal cord of rats, and most of the labeled cells
were located in the laminae I-II and V-VI. Som and EA suppressed the c-fos
expression and the lessening of FLI cells in the spinal cord.
CONCLUSION: Pathological pain following arthritis activated pain sensitive
neurons (PSN) and evoked c-fos expression in spinal cord, Som and EA suppressed
activities of these PSN, producing the effect of analgesia.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6983}
}