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Effects of Ro 31-8220 on smooth muscle cell proliferation induced by fibrinogen degradation products

   
@article{APS6978,
	author = {Bin Zhou and Jun-Ping Zhang and Zhen-Lin Hu and Xue-Bin Tao and Ding-Hua Qian},
	title = {Effects of Ro 31-8220 on smooth muscle cell proliferation induced by fibrinogen degradation products},
	journal = {Acta Pharmacologica Sinica},
	volume = {18},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the mitogenic activity of fibrin fibrinogen degradation products
(FFDP) and the effect of a new selectively potent protein kinase C (PKC)
inhibitor Ro 31-8220 (Ro).
METHODS: Rat aortic smooth muscle cells (SMC) proliferation in culture was
measured by crystal violet staining assay.
RESULTS: FFDP stimulated the proliferation of SMC during the experimental period 
of 72 h, Ro 0.01-1 mumol.L-1 inhibited FFDP-induced cell proliferation in a
concentration-dependent manner.
CONCLUSION: Ro exerted inhibitory effect on cell proliferation induced by FFDP.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6978}
}