@article{APS6969,
author = {Gao-Xing Zhang and Shou-Yue Pu and Ying-Zhen Yang and Xue-Dong Shen and Tian-Qing Peng and Hao-Zhu Chen},
title = {Effect of losartan and captopril on expression of cardiac angiotensin II AT1 receptor mRNA in rats following myocardial infarction},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of losartan (Los) and captopril (Cap) treatment on
expression of cardiac angiotensin II (Ang) AT1 receptor mRNA in rats following
myocardial infarction (MI).
METHODS: Twenty-four rats with MI after coronary ligation for 7 d were randomly
divided into 4 groups: A) Cap in drinking water, ad lib (2 g.L-1), B) i.g. Los 10
mg.kg-1.d-1, C) i.g. Los 30 mg.kg-1.d-1, and D) placebo for 6 wk. Sham-ligation
rats (group E) served as controls. The levels of cardiac Ang AT1 receptor mRNA
expression in each group (n = 6) were examined by Dot blot using
digoxigenin-labeled cDNA probes.
RESULTS: Comparing with reflected peak areas of hybridization positive signals in
group D (2640 +/- 201 micron 2), the expression of the cardiac Ang AT1 receptor
mRNA was much lower in the 3 treated groups (group A 1360 +/- 134 micron 2, group
B 1430 +/- 244 micron 2, group C 1310 +/- 95 micron 2) (P < 0.01). But no
difference was found between the 3 treated groups and sham-ligation group (1230
+/- 233 micron 2) (P > 0.05).
CONCLUSION: Los and Cap attenuated the increase of cardiac Ang AT1 receptor mRNA
expression in rats following MI.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6969}
}