@article{APS6926,
author = {Yan Sun and Chao-shu Tang and Hong-fang Jin and Jun-bao Du},
title = {The vasorelaxing effect of hydrogen sulfide on isolated rat aortic rings versus pulmonary artery rings},
journal = {Acta Pharmacologica Sinica},
volume = {32},
number = {4},
year = {2016},
keywords = {},
abstract = {Aim: To compare the vasorelaxing effects of hydrogen sulfide (H2S) on isolated aortic and pulmonary artery rings and to determine their action mechanisms.
Methods: H2S-induced vasorelaxation of isolated rat aortic versus pulmonary artery rings under 95% O2 and 5% CO2 was analyzed. The expression of cystathinonine gamma-lyase (CSE), cystathionine beta synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3MST), SUR2B and Kir6.1 was examined.
Results: NaHS caused vasorelaxation of rat aortic and pulmonary artery rings in a dose-dependent manner. NaHS dilated aortic rings to a greater extent (16.4%, 38.4%, 64.1%, 84.3%, and 95.9% at concentrations of 50, 100, 200, 500, and 1000 μmol/L, respectively) than pulmonary artery rings (10.1%, 22.2%, 50.6%, 73.6%, and 84.6% at concentrations of 50, 100, 200, 500 and 1000 μmol/L, respectively). The EC50 of the vasorelaxant effect for aortic rings was 152.17 μmol/L, whereas the EC50 for pulmonary artery rings was 233.65 μmol/L. The vasorelaxing effect of H2S was markedly blocked b y cellular and mitochondrial membrane KATP channel blockers in aortic rings (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6926}
}