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Pharmacokinetics of weekly transdermal estradiol controlled delivery system in postmenopausal Chinese

   
@article{APS6906,
	author = {Guo-Shen Chen and Mei-Yun Zhang and Qiao Wang and Jin-Cui Ye},
	title = {Pharmacokinetics of weekly transdermal estradiol controlled delivery system in postmenopausal Chinese},
	journal = {Acta Pharmacologica Sinica},
	volume = {17},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study Pharmacokinetical profile of weekly transdermal estradiol controlled delivery system (E2-WTCDS) in 18 Chinese postmenopausal women.
METHODS: Single and multiple daily doses of E2-WTCDS were applied to an area of intact skin on the lower abdomen, using Estraderm TTS (E2-TTS) from Ciba-Geigy Company as control. E2 concentration in serum was measured by RIA.
RESULTS: Cmax 38 +/- 5 ng.L-1, Tmax 22 +/- 5 h, AUC 5651 +/- 386 ng.h.L-1, Cmax(SS) 44 +/- 7 ng.L-1, Cmax(SS) 35 +/- 4 ng.L-1, Fl 0.22 +/- 0.10. The relative bioavailability of E2-WTCDS was comparable to E2-TTS during the same period of system application.
CONCLUSION: E2-WTCDS maintained relatively constant and effective serum estradiol concentrations and is suitable for once-weekly application.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6906}
}