@article{APS6898,
author = {Lin Zhou and Xiao-long Qi and Ming-xin Xu and Yu Mao and Ming-lin Liu and Hao-ming Song},
title = {Microparticles: new light shed on the understanding of venous thromboembolism},
journal = {Acta Pharmacologica Sinica},
volume = {35},
number = {9},
year = {2016},
keywords = {},
abstract = {Lin ZHOU1, #, Xiao-long QI2, #, Ming-xin XU2, #, Yu MAO1, Ming-lin LIU3, Hao-ming SONG1, *
1Division of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China; 2Division of Gastroenterology and Hepatology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China; 3Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia 19140, PA, USA
Microparticles are small membrane fragments shed primarily from blood and endothelial cells during either activation or apoptosis. There is mounting evidence suggesting that microparticles perform a large array of biological functions and contribute to various diseases. Of these disease processes, a significant link has been established between microparticles and venous thromboembolism. Advances in research on the role of microparticles in thrombosis have yielded crucial insights into possible mechanisms, diagnoses and therapeutic targets of venous thromboembolism. In this review, we discuss the definition and properties of microparticles and venous thromboembolism, provide a synopsis of the evidence detailing the contributions of microparticles to venous thromboembolism, and propose potential mechanisms, by which venous thromboembolism occurs. Moreover, we illustrate a possible role of microparticles in cancer-related venous thromboembolism.
Keywords: microparticle; blood cell; endothelial cell; venous thromboembolism; intercellular communication; inflammation; cancer
This study was supported by the Shanghai Municipal Bureau of Health Youth Scientific Research Projects (2009Y071) and the Shanghai Committee of Science and Technology Research Projects (11411951400).
# These authors contributed equally to this article.
* To whom correspondence should be addressed.
E-mail haomingsongtj@126.com
Received 2014-01-28 Accepted 2014-06-05},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6898}
}