@article{APS6860,
author = {Han-Xia Zhang and Zhi-Ming Xu and Zhi-Pu Luo and Bo-Yi Qin},
title = {Anxiogenic effect of naltrexone in social interaction test in rats},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM: To study the anxiogenic effect of naltrexone (Nal) on the emotional state of rats.
METHODS: The duration of active interaction was measured in the social interaction test in rats.
RESULTS: Without influence on the locomotor activity, Nal (0.1-50 mg.kg-1) dose- and time-dependently decreased the duration of active interaction, which was antagonized by morphine (5 mg.kg-1) or fenclonine (Fen, 150 mg.kg-1 x 3 d) and was enhanced by 5-hydroxytryptophan (5-HTP, 50 mg.kg-1).
CONCLUSIONS: Nal produced anxiety via its blockade of opioid receptors; central opioidergic neurons were involved in the regulation of anxiety through their tonic inhibitions in serotonergic neurons.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6860}
}