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Effects of nimodipine on acute cerebral ischemia and reperfusion injury of rats

  
@article{APS6858,
	author = {Mei-Xia He and Jun Ke and Zhi-Gang Li and Fang-Zhou Liu},
	title = {Effects of nimodipine on acute cerebral ischemia and reperfusion injury of rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {17},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effect of nimodipine (Nim) on ischemic cerebral damage.
METHODS: The four-vessel occlusion method was performed on rats. Monoamines were measured by fluorospectrophotometry.
RESULTS: Intraperitoneal injection of Nim 0.75 and 1.5 mg.kg-1 quickened the recovery of EEG changes to 19 +/- 3 and 17 +/- 4 min (P < 0.01), respectively. Nim reduced the decreases of monoamines (NE, DA, 5-HT, and 5-HIAA) contents after 30-min cerebral ischemia and 1-h reperfusion.
CONCLUSION: Nim protects the brain from ischemic damage.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6858}
}