@article{APS6855,
author = {Jia-Hui Lin and Guo-Yuan Hu and Xi-Can Tang},
title = {Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of huperzine-A on neuromuscular junction transmission in mouse.
METHODS: The isolated mouse phrenic nervehemidiaphragm preparations were used with the conventional intracellular recording technique. The spontaneous electrical activities of cholinergic nerve terminals (miniature end-plate potentials, MEPP) were recorded.
RESULTS: Huperzine-A, tacrine, and E2020 at the concentrations of 0.05-1 mumol.L-1 increased the amplitude, mean rise time, and half decay time of MEPP in a concentration-dependent manner. Their potencies were E2020 > huperzine-A > tacrine.
CONCLUSION: The anticholinesterase action of huperzine-A in cholinergic synapses is stronger than that of tacrine.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6855}
}