@article{APS6839,
author = {Marisol Ferraz and Emy L ISHII-IWAMOTO and Marcia R BATISTA Batista and Kellem Brunaldi and Roberto B Bazotte},
title = {Sorbitol accumulation in rats kept on diabetic condition for short and prolonged periods},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM: To study the influence of the course of diabetes, aging, and glycemia on the
sorbitol accumulation in diabetic rats.
METHODS: Streptozocin (Str) diabetic rats were obtained by Str i.v. (35 mg.kg-1).
Glycemia and sorbitol levels from sciatic nerve and lens were measured after 1 d,
2, 5, and 8 months of diabetes. Sorbitol concentrations in serum, heart,
diaphragm, small intestine, and kidney after 8 months of diabetes were measured.
RESULTS: Diabetic rats after Str injection showed hyperglycemia (> 1.7 g.L-1),
hyperphagia, polyuria, polydipsia, and loss of body weight. Sorbitol levels in
lens and sciatic nerve increased in normal and diabetic rats; the increase was
higher in diabetic rats. No relationship was shown between glycemia and sorbitol
levels. An increased sorbitol level after 8 months of diabetes was found in small
intestine and kidney.
CONCLUSION: The sorbitol levels increased in lens and sciatic nerve with aging
and this process was accelerated by diabetes.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6839}
}