@article{APS6816,
author = {Hong Li and Yong-Feng Jia and Yan Pan and De-Ji Pan and Duan Li and Luo-Xiu Zhang},
title = {Effect of tripterine on collagen-induced arthritis in rats},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the therapeutic effect of tripterine (Tri) on collagen-induced
arthritis (CIA).
METHODS: Collagen type II (Col) 1.5 mg was injected intradermally to induce CIA
in rats. Hind paw volumes of rats were measured with a water displacement method.
The serum anti-collagen antibody was measured by an enzyme-linked immunosorbent
assay. Delayed hypersensitivity was reflected by skin response to Col.
Interleukin-1 (IL-1) and interleukin-2 (IL-2) activities were evaluated by
[3H]TdR uptake. Joint was evaluated histologically.
RESULTS: Tri 15 and 30 mg.kg-1.d-1 given i.g. to rats 3 d after the first sign of
arthritis reduced inflammatory swelling, suppressed humoral and skin response to
Col, inhibited IL-2 and IL-1 production, reduced pathological progression of
joint.
CONCLUSION: Tri has a therapeutic effect on CIA.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6816}
}