@article{APS6788,
author = {Jing-Dong Zhang and Kihachi Saito},
title = {Carbamazepine facilitates effects of GABA on rat hippocampus slices.},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the influence of carbamazepine (Car) on GABA effect in hippocampus.
METHODS: Evoked potentials were recorded on pyramidal cells in CA1 after
stimulation (0.5 Hz, 50 microseconds) to Schaffer collaterals in rat hippocampal
slices (350 microns).
RESULTS: Car 0.1 and 0.2 mmol.L-1 did not affect field potentials, whereas Car
0.2 mmol.L-1 plus GABA (0.1-1 mmol.L-1) gave rise to a stronger inhibition on
field potentials than that of GABA alone. Bicuculline did not reverse Car
facilitation on GABA inhibition on field potentials. (-)-Baclofen was more
effective in inhibiting field potentials than GABA. Car 0.2 mmol.L-1 plus
(-)-baclofen (1-5 mumol.L-1) brought an inhibition stronger than that of
(-)-baclofen alone.
CONCLUSION: Car facilitates the effects of GABA on pyramidal cells in hippocampal
CA1 region, probably related to GABAB receptors.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6788}
}