How to cite item

Protection of ebselen against anoxic damage of cultured neurons of cerebral cortex

   
@article{APS6769,
	author = {Ye-Xiong Tan and Wan-Hai Li and Xue-Bin Tao and Yuan-Ying Jiang and Wei-Ping Chen and Bin Zhou},
	title = {Protection of ebselen against anoxic damage of cultured neurons of cerebral cortex},
	journal = {Acta Pharmacologica Sinica},
	volume = {18},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the protective effect of ebselen on anoxic damage of brain cells.
METHODS: On d 10 after plating of the cortical neurons from 1-d-old rat, cultures
were placed under 95% N2 + 5% CO2 for 2-6 h. Lactate dehydrogenase (LDH) in
supernatant, thiobarbituric acid reactive substance (TBARS) and glutathione
peroxidase (GSH-Px) activity of neurons were determined.
RESULTS: Under anoxia, efflux of LDH and TBARS from cultured neurons increased
while GSH-Px activity decreased. Ebselen reduced the efflux of LDH and TBARS in a
dose-related manner and increased the total GSH-Px activity.
CONCLUSION: Ebselen can protect neurons from anoxic damage.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6769}
}