TY - JOUR AU - Jiang Cheng-shi AU - Liang Lin-fu AU - Guo Yue-wei PY - 2016 TI - Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades JF - Acta Pharmacologica Sinica; Vol 33, No 10 (October 2012): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented. UR - http://www.chinaphar.com/article/view/6767