@article{APS6766,
author = {Pei-Li Gong and Yong-Long Li and You-Ren Feng and Andreas Puppel and Conor Caffrey},
title = {Inhibitory effect of artemether on proteinase of Schistosoma japonicum.},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the effect of artemether (Art) on the thio proteinase
(\"\"hemoglobinase\"\", Hem) of Schistosoma japonicum.
METHODS: Hem was extracted from S japonicum adults. The inhibitory effect of Art
on the activity of Hem to degrade human hemoglobin (Hgb) was examined with
UV-photometer at 280 nm, SDS-PAGE and scanning at 600 nm on a chromoscanner.
RESULTS: Human Hgb was degraded at pH 4.0 by the Hem. The activities of Hem
preincubated at 37 degrees C with Art 0.14, 1.4, and 14 mmol.L-1, were inhibited
by 30.2%, 39.8%, and 45.0%, respectively.
CONCLUSION: Art possesses an inhibitory effect to Hem of S japonicum.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6766}
}