TY - JOUR AU - Tu Yuan-chao AU - Ding Hu AU - Wang Xiao-jing AU - Xu Yu-jun AU - Zhang Lan AU - Huang Cong-xin AU - Wang Dao-wen PY - 2016 TI - Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD JF - Acta Pharmacologica Sinica; Vol 31, No 7 (July 2010): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aim: To assess the epistatic relationships of nitric oxide (NO) biosynthesis pathway genes in susceptibility to coronary heart disease (CHD). Methods: A total of 2142 subjects enrolled in two case-control studies was genotyped for 7 single-nucleotide polymorphisms (SNP) within NO biosynthesis pathway genes using TaqMan assays. The association analyses were performed at both SNP and haplotype levels. Two-way SNP-SNP interactions and high-order interactions were tested using multiple unconditional logistic regression analyses and generalized multifactor dimensionality reduction (GMDR) analyses, respectively. Results: Two alleles (rs1049255*C and rs841*A) were identified that were significantly associated with increased risk of CHD after adjusting for all confounders (OR=1.21, 95% CI: 1.06−1.39, combined P=0.001, P corr =0.007 and OR=1.30, 95% CI 1.12−1.50, combined P P corr Conclusion: The results suggested that two-way SNP–SNP interactions of polymorphisms within NO biosynthesis pathway genes contribute to CHD risk. UR - http://www.chinaphar.com/article/view/6732