@article{APS6732,
author = {Yuan-chao Tu and Hu Ding and Xiao-jing Wang and Yu-jun Xu and Lan Zhang and Cong-xin Huang and Dao-wen Wang},
title = {Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD},
journal = {Acta Pharmacologica Sinica},
volume = {31},
number = {7},
year = {2016},
keywords = {},
abstract = {Aim: To assess the epistatic relationships of nitric oxide (NO) biosynthesis pathway genes in susceptibility to coronary heart disease (CHD).
Methods: A total of 2142 subjects enrolled in two case-control studies was genotyped for 7 single-nucleotide polymorphisms (SNP) within NO biosynthesis pathway genes using TaqMan assays. The association analyses were performed at both SNP and haplotype levels. Two-way SNP-SNP interactions and high-order interactions were tested using multiple unconditional logistic regression analyses and generalized multifactor dimensionality reduction (GMDR) analyses, respectively.
Results: Two alleles (rs1049255*C and rs841*A) were identified that were significantly associated with increased risk of CHD after adjusting for all confounders (OR=1.21, 95% CI: 1.06−1.39, combined P=0.001, Pcorr=0.007 and OR=1.30, 95% CI 1.12−1.50, combined P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6732}
}