%0 Journal Article %T Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-α genes with body mass index (BMI) in premenopausal Chinese women %A Xu Hong %A Xiao Wen %A Luo Dan %A Liu Yong-ming %A Zou Lin %A Kuang Hai-bin %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-α genes with body mass index (BMI) in premenopausal Chinese women %K %X Aim: To investigate whether estrogen receptor α (ER-α) Pvu II and osteocalcin (also known as bone Gla protein, or BGP) Hind III genetic polymorphisms and their potential interactions are associated with body mass index (BMI) variation. Methods: Data on BMI and ER-α Pvu II and BGP Hind III genotypes were obtained from 328 healthy premenopausal Chinese women in east China. The study subjects were unrelated, at least 21 years old (mean age of 33.2±5.9 years), and had an average BMI of 21.58±2.59. All subjects were genotyped at the ER-α Pvu II and BGP Hind III loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Results: The BGP Hind III genotypes were significantly associated with BMI (P=0.003). Carriers of the HH and Hh genotypes had approximately 2.73% and 1.27% higher BMI than those of the hh genotype, respectively. In contrast, the ER-α Pvu II polymorphism was not significantly associated with BMI ( P =0.454). In addition, there was no evidence of potential interactions between the ER-α and BGP genes in our subjects ( P ≥0.013). Conclusion: The Hind III polymorphism of the BGP gene, but not the Pvu II polymorphism of the ER-α gene or their potential interaction, was associated with BMI in premenopausal Chinese women. %U http://www.chinaphar.com/article/view/6686 %V 31 %N 4 %P 455–460 %@ 1745-7254