@article{APS6610,
author = {Jian-gang Yang and Nai-xue Sun and Li-jun Cui and Xiao-hua Wang and Zhao-hui Feng},
title = {Adenovirus-mediated delivery of p27 KIP1 to prevent wound healing after experimental glaucoma filtration surgery},
journal = {Acta Pharmacologica Sinica},
volume = {30},
number = {4},
year = {2016},
keywords = {},
abstract = {Aim: The aim of the study was to evaluate the outcome of adenovirus-mediated p27KIP1 (Ad-p27) expression on wound healing after filtration surgery and to investigate the inhibition of cell proliferation induced by Ad-p27.
Methods: We constructed the adenovirus recombinant vector Ad-p27 and administered it to a rabbit model of glaucoma filtration surgery by subconjunctival injection; phosphate-buffered saline (PBS) and mitomycin C (MMC) were used as controls. Intraocular pressure (IOP), bleb scores, and anterior chamber depths were observed during a 28-d period. Histological examinations, fluorescence observations and Western blot analyses were evaluated.
Results: Ad-p27 enhanced the surgical outcome and inhibited cell proliferation when compared with PBS. Bleb scores in the Ad-p27-treated eyes were higher than those in the PBS-treated eyes on d 7 (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6610}
}