@article{APS6601,
author = {Su-li Zhang and Yun-hui Du and Jin Wang and Li-hong Yang and Xiao-li Yang and Rong-hua Zheng and Ye Wu and Ke Wang and Ming-sheng Zhang and Hui-rong Liu},
title = {Endothelial dysfunction induced by antibodies against angiotensin AT1 receptor in immunized rats},
journal = {Acta Pharmacologica Sinica},
volume = {31},
number = {10},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the association between autoantibodies against angiotensin AT1 receptor (AT1-AAs) and endothelial dysfunction in vivo.
Methods: Rat models with AT1 receptor antibodies (AT1-Abs) were established by active immunization for nine months. Lactate dehydrogenase (LDH) activity was regarded as an indicator of cell necrotic death. Endothelin-1 (ET-1) in the sera of rats was determined and endothelium-dependent vasodilatation was detected in isolated thoracic aorta. Endothelial intercellular adhesion molecule-1 (ICAM-1) expression in aorta endothelium was assessed using confocal microscopy. Coronary artery endothelial ultrastructure was observed.
Results: IgGs in the immunized group significantly increased the LDH activity (0.84±0.17 vs 0.39±0.12, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6601}
}